Traditional Chinese medicine ingredient Asiaticoside(Gotu Kola Extract) - a new hope for the treatment of chronic kidney disease

Chronic kidney disease (CKD) affects over 10% of the global population, and renal fibrosis is a common pathological basis for its progression to end-stage renal disease. However, there is still a lack of effective targeted therapeutic drugs in clinical practice. Recently, Professor Liu Bicheng's team from the Department of Nephrology at Southeast University Affiliated Zhongda Hospital published a groundbreaking study, which for the first time elucidated at the molecular level how traditional Chinese medicine- Asiaticoside(Gotu Kola Extract) can accurately combat renal fibrosis!

Renal fibrosis -- the "ultimate Boss" of chronic kidney disease. No matter whether you are lqA nephropathy, diabetes nephropathy or membranous nephropathy, they will all go the same way -- renal fibrosis. The kidney tissue is gradually replaced by scars, ultimately leading irreversibly to uremia. The global medical community has been struggling for decades, but has never found a perfect "bomb disposal" solution.

What did Liu Bicheng's team discover in their research?

Asiaticoside (AS) can directly penetrate into the "joint cavity" (SH2 domain) of STAT3 protein, inducing its conformational degradation through "binding and destabilization". AS is like a precise molecular gripper that breaks down the "bad protein" STAT3 that causes inflammation and fibrosis!

The study not only endows  Asiaticoside(Gotu Kola Extract), an ancient traditional Chinese medicine ingredient, with new pharmacological connotations, but also proposes a new STAT3 targeted strategy of "binding and destabilizing" conformational degradation, providing important scientific basis and new ideas for the development of innovative drugs for the treatment of renal fibrosis and other STAT3 driven fibrosis diseases (such as liver fibrosis, pulmonary fibrosis, cancer, etc.).

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